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Clopidogrel and Proton Pump Inhibitors: What You Need to Know About the Reduced Antiplatelet Effect
March 7 2026 by Aiden Fairbanks

Clopidogrel and Proton Pump Inhibitors: What You Need to Know About the Reduced Antiplatelet Effect

Clopidogrel and certain PPIs like omeprazole can interact, reducing clopidogrel’s antiplatelet effect and increasing heart attack risk. Pantoprazole and rabeprazole are safer alternatives. Know which PPIs to avoid and what to ask your doctor.

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