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Therapeutic Equivalence Codes: How the FDA Determines If Generic Drugs Can Be Substituted
March 6 2026 by Aiden Fairbanks

Therapeutic Equivalence Codes: How the FDA Determines If Generic Drugs Can Be Substituted

Therapeutic equivalence codes from the FDA tell pharmacists which generic drugs can be safely swapped for brand-name medications. Learn how the Orange Book's A and B ratings work, why some generics aren't interchangeable, and how this system saves billions in healthcare costs.

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