Wellbutrin (Bupropion) – Uses, Dosage, Side Effects & Alternatives

If you’ve heard the name Wellbutrin, you probably know it’s an antidepressant that works differently from SSRIs. It’s also sold as bupropion and prescribed for depression, seasonal mood swings, and to help quit smoking. In this guide we’ll break down what it does, how doctors dose it, the side effects you might notice, and a few solid alternatives if Wellbutrin isn’t right for you.

How Wellbutrin Works

Wellbutrin boosts the levels of dopamine and norepinephrine in your brain. Those chemicals help with focus, energy and mood, which is why many people feel less sluggish on this med. Because it doesn’t hit serotonin much, you’re less likely to get the weight gain or sexual side effects common with other antidepressants.

Typical Dosage & How to Take It

Doctors usually start adults at 150 mg once daily for the first three days, then increase to 300 mg split into two doses. For smoking cessation, the dose often goes up to 350 mg a day. You should take the tablets with food to avoid stomach upset and try to keep the schedule consistent – missing a dose can cause headaches or irritability.

Never double‑up if you forget one; just skip it and continue as usual. If you’re switching from another antidepressant, your doctor might taper the old drug first to cut down on withdrawal symptoms. Always follow the exact plan your prescriber gives you.

Common Side Effects & Safety Tips

The most frequent complaints are dry mouth, insomnia and a slight increase in heart rate. Some folks feel a mild headache or nausea during the first week – that usually fades as your body adjusts. A rare but serious risk is seizures, especially if you take more than 450 mg daily or have a history of eating disorders.

To keep things safe, stay hydrated, avoid alcohol and talk to your doctor about any other meds you’re on, especially other antidepressants or antipsychotics. If you notice mood swings, thoughts of self‑harm, or an allergic reaction like rash or swelling, get medical help right away.

Wellbutrin Alternatives

If Wellbutrin’s side effects bother you or it doesn’t lift your mood enough, there are other options. SSRIs such as Zoloft or Lexapro target serotonin and work for many people, though they can cause weight gain. SNRIs like Cymbalta hit both serotonin and norepinephrine, offering a middle ground.

Atypical antidepressants such as Trintellix (vortioxetine) or Remeron (mirtazapine) have different mechanisms that might suit you better. Talk to your clinician about your symptom profile – sometimes a simple switch can make a big difference.

Bottom Line

Wellbutrin is a solid choice for depression, seasonal affective disorder and smoking cessation because it energizes rather than sedates. Know the typical dosing schedule, watch for common side effects, and keep an open line with your doctor about any concerns. And remember, if Wellbutrin isn’t clicking, plenty of other antidepressants can fill the gap. Your mental health journey is personal – find the pill that works best for you and stick with it under professional guidance.